I find the effect from this B-2 very noticeable, unlike regular non co-enzymated B2. I think my digestion/methylation is too weak so I respond only to coenzyme form of b vitamins. It is the same with B1 for me.
My Doctor found I had a severe deficiency of Vitamin B 2 and I had very bad headaches as a result. I had to take weekly injections of Vitamin B 2. Then I found this sublingual supplement available! Now I use this product instead. My doctor routinely monitors my lab values for the correct dose. It really gave me my freedom back to travel. Thank you!